In drawing.tool the y-axis defines North-South for the project when drawing the building. When looking at the drawing.tool grid North will be up the page, and South will be down the page (towards where the grid ends). north can also be seen via the compass available while in 3D view.
In loadmodeling.tool, the Project Orientation input allows users to specify the specific orientation of their project's geometry before the model is run.
The input will rotate the building the entered number of degrees East from the north Access. Another way to visualize this is the input rotates the simulation engine's North axis counterclockwise relative to the drawing.tool model y-axis.
Below is an example of how a 20-degree rotation looks in the settings, drawing.tool, and in the OpenStudio export:
You can find the Project Orientation input in the Simulation Settings page.
The Project Orientation input in the settings will not impact how the building looks in drawing.tool. It is accounted for in the load calculation simulation only.
In the screenshot below, the orange line represents the true North axis. It has been rotated 20 degrees counterclockwise from the geometry's y-axis (green line). Alternatively, this means that the grid that the building sits on is rotated 20 degrees clockwise from the true North axis.